Blood-brain barrier tight junction permeability and ischemic stroke.

The blood-brain barrier (BBB) is shaped by the endothelial cells of cerebral microvessels, offering a dynamic interface between the peripheral circulation and the central nervous system. The tight junctions (TJs) between the endothelial cells serve to limit blood-borne substances from getting into the mind. Under ischemic stroke circumstances decreased BBB TJ integrity leads to elevated […]