Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) causes secondary mind damage resulting from vasospasm and irritation. Here, we studied a rat mannequin of mild-to-moderate SAH supposed to attenuate ischemia/hypoxia to look at the function of sulfonylurea receptor 1 (SUR1) within the inflammatory response induced by SAH. mRNA for Abcc8, which encodes SUR1, and SUR1 protein have been abundantly upregulated […]